Many years ago and many 22-250's ago I began loading 50 grain bullets and H380 powder. When I got the current 22-250 I was getting ready to go on a Pdog shoot and didn't have a lot of time to develope a load so I dumped 37 grains of H380 in a new Win case with CC! standard primer and a Hornady 50 VMAX bullet. I shot 4 groups and they ran .400, .375, .232 and .545 at 100 yards. Haven't seen any reason to change things. Over the years I have tried different powders and many different bullets in other rifles. I like H380 because it flows so well and I also use it in other rifles.